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一角獣 is the Japanese name for the western unicorn (a horse with a spiral horn emerging from the head). This can also refer to a narwhal, depending on context.
一角獣 is an unusual title for a Japanese wall scroll but it's OK if you really love unicorns.
Japanese have their own ancient unicorn-like creature called a “kirin” (or qilin in the original Chinese).
麒麟 is the title of a mythical beast of Asia.
The animal is thought to be related to the giraffe, and in some ways, it is a giraffe. However, it is often depicted with the horns of a dragon or deer and sometimes with the body like a horse, but many variations exist.
In Japanese, it is pronounced “Kirin” as in “Kirin Ichiban” beer.

Notes:
1. This is sometimes spelled as “kylin.”
2. In Japanese, this is the only Kanji word for giraffe. Therefore in Japan, this word needs context to know whether you are talking about the mythical creature or the long-necked giraffe of Africa.
3. Apparently, this was the first word used for regular giraffes in China (some were brought from Africa to China during the Ming Dynasty - probably around the year 1400). Though the mythical creature may have existed before, the name “qilin” was given to the “new giraffe.” This is because, more than 600 years ago, giraffes somewhat matched the mythical creature's description when Chinese people saw them for the first time. Later, to avoid such an ambiguous title, a three-character word was devised to mean a “giraffe of Africa.” The characters for “qilin” shown here are only for the mythological version in modern Chinese.
4. More information about the qilin / kirin from Wikipedia.
5. This creature is sometimes translated as the “Chinese Unicorn,” although it is generally portrayed with two horns. I think this is done more for the fantasy aspect of the unicorn and because most westerners don't know what a qilin or kirin is (this avoids a long explanation by the translator).
6. In Korean, this can mean kirin or simply giraffe (usually, the mythological creature is what they would think of when seeing these characters alone on a wall scroll).